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The progressive changes in the retina that occur in patients with diabetes include the following Formation of retinal capillary microaneurysms Development of abnormal vascular permeability Ischemia New vessel and fibrous tissue proliferation of the surface of the retina and optic disk Contraction of the fibrovascular proliferations and the vitreous 13 Nephropathy The diagnosis of nephropathy is initially based on development of microalbuminuria Microalbuminuria is defined as an albumin excretion rate 20 to 200 mcgmin.

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